Diagnostic performance of electrocardiographic criteria for left ventricular hypertrophy in hypertensive patients: a comparative analysis against echocardiography.
DOI:
https://doi.org/10.62059/rj9q7m20Keywords:
Arterial hypertension, Left ventricular hypertrophy, Electrocardiogram, Diagnostic performanceAbstract
Introduction: Left ventricular hypertrophy (LVH) is a complication of hypertension associated with increased cardiovascular risk. Objective: To determine the prevalence of LVH using different electrocardiographic criteria and evaluate their diagnostic performance in outpatient hypertensive patients. Materials and Methods: An observational, analytical, cross-sectional study was conducted in 246 adult patients with arterial hypertension attending outpatient care in 2024. The electrocardiographic criteria analyzed included Sokolow–Lyon, Cornell, Peguero Lo-Presti, and Romhilt–Estes. LVH was defined by echocardiography using the left ventricular mass index as the reference standard. Sensitivity, specificity, predictive values, accuracy, area under the curve (AUC), and p-values were calculated, along with stratified analyses according to clinical variables. Results: The prevalence of LVH by echocardiography was 39%, while ECG-based prevalence ranged from 13.4% to 19.9%. The Romhilt–Estes criterion showed the best performance, with a sensitivity of 42%, specificity of 94%, and an AUC of 0.687. The remaining criteria demonstrated lower sensitivities (21%–35%) and inferior AUC values (0.569–0.634). All criteria showed a significant association with LVH (p ≤ 0.003). Diagnostic performance varied according to sex, body mass index, and blood pressure control. Conclusions: ECG shows low sensitivity but high specificity for detecting LVH, with limited discriminative ability. The Romhilt–Estes criterion demonstrated the best overall performance. ECG is useful for initial risk stratification but does not replace echocardiography.References
1 World Health Organization. Hypertension fact sheet. Geneva: World Health Organization; 2023.
2 NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and control from 1990 to 2019: a pooled analysis of 1,201 population-representative studies with 104 million participants. Lancet. 2021;398(10304):957-80.
3 Palmieri V, Dahlöf B, DeQuattro V, et al. Reliability of echocardiographic assessment of left ventricular structure and function: the PRESERVE study. Prospective Randomized Study Evaluating Regression of Ventricular Enlargement. J Am Coll Cardiol 1999;34: 1625–32
4 Maunganidze F, Woodiwiss AJ, Libhaber CD, Maseko MJ, Majane OH, Norton GR. Left ventricular hypertrophy detection from simple clinical measures combined with electrocardiographic criteria in a group of African ancestry. Clin Res Cardiol 2014;103:921–9.
5 Mahn JJ, Dubey E, Brody A, et al. Test characteristics of electrocardiography for detection of left ventricular hypertrophy in asymptomatic emergency department patients with hypertension. Acad Emerg Med 2014;21:996–1002.
6 Devereux RB, et al. Electrocardiographic detection of left ventricular hypertrophy. Circulation. 1984;69(4):802-10.
7 Narayanan K, Reinier K, Teodorescu C, et al. Electrocardiographic versus echocardiographic left ventricular hypertrophy and sudden cardiac arrest in the community. Heart Rhythm 2014;11: 1040–6.
8 Barrios Alonso X, et al. Diagnóstico de la hipertrofia ventricular izquierda por electrocardiografía: utilidad de los nuevos criterios. Rev Costarric Cardiol. 2004;6(3).
9 Hancock E.W., Deal B.J., Mirvis D.M., Okin P., Kligfield P. and Gettes L.S.: AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part V: electrocardiogram changes associated with cardiac chamber hypertrophy: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol 2009; 53: 992.
10 Díez J. Mechanisms of cardiac fibrosis in hypertension. J Clin Hypertens (Greenwich). 2007;9(7):546-50.
11 Lorell BH, Carabello BA. Left ventricular hypertrophy: pathogenesis, detection, and prognosis. Circulation. 2000;102(4):470-9.
12 Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2022 AHA/ACC Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. Hypertension. 2022;79(6):e1-e24.
13 Cuspidi C, Sala C, Negri F, Mancia G, Morganti A; Italian Society of Hypertension. Prevalence of left-ventricular hypertrophy in hypertension: an updated review of echocardiographic studies. J Hum Hypertens. 2012 Jun;26(6):343-9.
14 Wang SX, Xue H, Zou YB, Sun K, Fu CY, Wang H, Hui RT. Prevalence and risk factors for left ventricular hypertrophy and left ventricular geometric abnormality in the patients with hypertension among Han Chinese. Chin Med J (Engl). 2012 Jan;125(1):21-6. PMID: 22340460.
15 Mancia G, Kreutz R, Brunström M, Burnier M, Grassi G, Januszewicz A, et al. 2023 ESH Guidelines for the management of arterial hypertension. J Hypertens. 2023;41(12):1874-2071.
16 Bacharova L, Ugander M. Left ventricular hypertrophy: The relationship between the electrocardiogram and cardiovascular magnetic resonance imaging. Ann Noninvasive Electrocardiol. 2014 Nov;19(6):524-33.
17 Casale PN, Devereux RB, Alonso DR, Campo E, Kligfield P. Improved sex-specific criteria of left ventricular hypertrophy for clinical and computer interpretation of electrocardiograms: validation with autopsy findings. Circulation. 1987 Mar;75(3):565-72.
18 Surawicz B, Childers R, Deal BJ, Gettes LS, Bailey JJ, Gorgels A, Hancock EW, Josephson M, Kligfield P, Kors JA, Macfarlane P, Mason JW, Mirvis DM, Okin P, Pahlm O, Rautaharju PM, van Herpen G, Wagner GS, Wellens H; American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; American College of Cardiology Foundation; Heart Rhythm Society. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventricular conduction disturbances: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol. 2009 Mar 17;53(11):976-81.
19 Sokolow M, Lyon TP. The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads. Am Heart J. 1949 Feb;37(2):161-86.
20 Romhilt DW, Estes EH Jr. A point-score system for the ECG diagnosis of left ventricular hypertrophy. Am Heart J. 1968 Jun;75(6):752-8.
Downloads
Status: Under review
in Revista Argentina de MedicinaRAM is a quarterly publication edited and financed by the Argentine Society of Medicine aimed at disseminating biomedical, epidemiological and social scientific topics related to the following branches of clinical medicine: bioethics, cardiology, critical care, palliative care, dermatology, pain, education, emergentology, endocrinology, epidemiology, pharmacology and…
Downloads
Posted
Categories
License
Copyright (c) 2026 Brayan Paúl Carrión Ruiz, Freddy Ramón Pow Chon Long Moran, Omar Eduardo Medina Campozano (Autor/a)

This work is licensed under a Creative Commons Attribution 4.0 International License.
This preprint contains the reported license and associated copyright. Once published in an associated journal or other publisher, the published version assumes the publisher's terms and conditions.