Preprint / Versión 1

El ensayo clínico diana para inferencia causal en estudios observacionales

Autores/as

DOI:

https://doi.org/10.62059/LatArXiv.preprints.70

Palabras clave:

Ensayo clínico diana, Emulación, Ensayos clínicos, Inferencia causal

Resumen

El uso de estudios observacionales para inferencia causal es una necesidad, ya que no hay ensayos clínicos aleatorizados disponibles siempre. Para reducir fuentes de sesgo presentes en estudios observacionales “clásicos”, se ha propuesto utilizar el marco del ensayo clínico diana. Bajo este marco, se definen al menos los siguientes componentes  del protocolo del ensayo clínico pragmático que hubiéramos querido realizar: criterios de elegibilidad, estrategias de tratamiento, métodos de asignación, periodo de seguimiento, desenlace, contrastes causales y plan de análisis. Posteriormente, estos se modifican en base a los datos observacionales disponibles y se utilizan para emular el ensayo clínico diana lo más de cerca posible. Esto resulta en estudios observacionales con menos sesgo y resultados más confiables. Sin embargo, es importante considerar las limitaciones de este enfoque, ya que sigue tratándose de un estudio observacional y no de un experimento aleatorizado.

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PrePrint online

2024-05-24

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